This is a bit of a longer blog, but very insightful. Part 1 of 2.
By Dr. Ben Kim
You have countless immune cells in every corner of your body that
are constantly working to keep you healthy by identifying, packaging,
and eliminating harmful substances that have made their way into your
blood.
If your immune system falters and begins to identify some of your own
tissues as being harmful or unnecessary, it will work to attack and
eliminate these tissues through an inflammatory response that can cause
pain and discomfort in many forms - this is how autoimmune illness
develops.
The specific tissue or groups of tissues (organs) that your immune system decides to attack is determined by your genetics.
But just because you have a genetic predisposition for an autoimmune
illness does not mean that you are guaranteed to experience it sometime
during your life, or that you cannot recover from it.
Genetic predispositions are largely triggered, maintained, and kept
under control by environmental factors, namely, your diet, lifestyle,
and how much stress you experience.
Ultimately, the development of autoimmune illness requires that your
immune system begins to identify some of your own cells as being
harmful, and that control mechanisms that are in place to prevent such
"glitches" no longer do what they are supposed to in preventing such
occurrences.
There are several theories that attempt to explain why and how these
glitches occur. Rather than get into biochemical jargon that will not do
much, if anything, to help you get better, we can explain these
glitches in the following way:
Over time, as your cells are abused by lack of rest, lack of optimal
nourishment, accumulation of waste products, and direct insult by
excessive amounts of free radicals and toxins, your cells gradually
become less efficient at eliminating waste products and exogenous toxins
(toxins that are produced outside of your body).
Eventually, waste products and toxins may incorporate themselves into
your cell membranes, and if this happens, your immune system may
identify such cells as being old and damaged. At that point, your immune
system will work to attack and eliminate such cells from your body.
How does your immune system go about attacking and eliminating such
cells? By producing antibodies, attaching said antibodies to the cell
membranes of cells that have been identified as old and damaged, and
then sending other components of your immune system to destroy these
antibody-tagged cells. Your immune system destroys such cells using a
process of inflammation, which is why autoimmune illness is often
accompanied by discomfort.
If your genetic predisposition is such that the majority of cells
that are tagged to be destroyed are clustered around your thyroid gland,
your health challenges may be attributed to a diagnosis of Graves’
disease. If your abnormal-looking cells are in the fatty, insulating
sheath (myelin) that surrounds your nervous system, you may exhibit
symptoms of multiple sclerosis. If your genetically weak tissues are
those that line your joints, destruction of old and damaged cells in and
around your joints may be diagnosed as rheumatoid arthritis.
Ultimately, the underlying inflammatory process that accompanies
autoimmune disease is the same for all of the following names that we
have created for different groups of symptoms:
Acute disseminated encephalomyelitis (ADEM) involves inflammation in the brain that typically occurs a few days or weeks after a vaccination or a viral infection.
Addison's disease involves dysfunction of the outer portion of the adrenal gland.
Ankylosing spondylitis is a type of arthritis that involves inflammation of the spine and pelvic joints.
Antiphospholipid antibody syndrome (APS) is a condition that affects the blood-clotting process, causing blood clots to form in veins and/or arteries.
Aplastic anemia is a condition whereby the bone
marrow does not produce enough blood cells. It is often caused by an
autoimmune attack on the bone marrow.
Autoimmune hepatitis involves inflammation of the liver.
Celiac disease is characterized by chronic
inflammation of the first third or half of the small intestine, and is
caused by exposure to a type of dietary protein called gluten, found in
abundance in grains like wheat, oats, barley, and rye.
Crohn's disease involves chronic inflammation of the intestinal tract.
Diabetes Mellitus Type 1 is characterized by low or non-existent production of insulin by the pancreas.
Goodpasture's syndrome involves destruction of kidney tissue and bleeding in the lungs.
Graves' disease is a form of hyperthyroidism.
Guillain-Barré syndrome (GBS) involves inflammation
of the peripheral nervous system, and is also called acute inflammatory
demyelinating polyneuropathy, acute idiopathic polyradiculoneuritis,
acute idiopathic polyneuritis and Landry's ascending paralysis.
Hashimoto's disease is a form of hypothyroidism.
Idiopathic thrombocytopenic purpura is characterized by a low platelet count, resulting in easy bleeding.
Systemic lupus erythematosus (SLE) is a chronic
autoimmune condition that can involve inflammation in the following
areas: skin, joints, heart, lungs, kidneys, and nervous system.
Multiple sclerosis involves nerve dysfunction due to demyelination of the central nervous system.
Myasthenia gravis involves intermittent weakness and fatigue due to a problem with communication at the junction of nerves and muscles.
Optic neuritis involves inflammation of the nerves that supply your eyes which can cause partial or complete loss of vision.
Pemphigus is characterized by the formation of blisters and raw sores on mucous membranes and skin.
Pernicious Anemia is a form of anemia (inadequate
red blood supply/function) that is caused by a problem with absorbing
vitamin B12, which is needed to form healthy red blood cells.
Rheumatoid arthritis is characterized by joint pain and inflammation.
Sjögren's syndrome involves destruction of glands that produce saliva and tears.
Takayasu's arteritis is characterized by inflammation that narrows the lumen of arteries.
Temporal arteritis is characterized by inflammation
in medium to large-sized arteries, mostly commonly in the head. It is
sometimes called giant cell arteritis, and can lead to significant
vision loss.
Warm autoimmune hemolytic anemia is characterized by destruction of red blood cells by IgM antibodies.
Wegener's granulomatosis involves inflammation of blood vessels, typically affecting the kidneys and lungs.
Diagnoses that are not universally accepted as being autoimmune in
nature, but for all practical purposes belong in the same category of
health conditions, include:
Alopecia is characterized by hair loss. Loss of random
patches is called alopecia areata, while full body loss of hair is
called alopecia universalis.
Endometriosis is characterized by endometrial tissue
(tissue found in the uterus) being deposited outside of the uterus,
causing pain and sometimes infertility.
Interstitial cystitis is a urinary bladder disease
that is characterized by one or more of the following symptoms: intense,
intermittent pelvic pain, frequent urination, a sense of urgency to
urinate, pain with urination, and pain with sexual intercourse.
Psoriasis is a skin condition that is characterized by patches of rapidly-dividing cells that produce itchy, scaly, and inflamed lesions.
Sarcoidosis is characterized by granuloma formation in the lungs and sometimes throughout the body.
Schizophrenia is characterized by impairments in the
perception or expression of reality, often leading to social and
occupational dysfunction.
Scleroderma is characterized by excessive deposits of collagen throughout the body.
Ulcerative colitis is characterized by inflammation in the bowel, typically in the distal section of the large bowel and rectum.
Vitiligo is characterized by gradual loss of pigmentation in patches across the face and/or body.
All of these conditions may be caused, in part, by cells in the
problematic regions becoming old, damaged, and congested enough to be
tagged by your immune system as being ready for destruction and removal.
But there is another major mechanism by which all autoimmune
illnesses can develop and worsen. Whenever any unnecessary, harmful, or
unidentifiable substances enter your bloodstream, they get noticed by
your immune system. In an effort to preserve your health, your immune
system produces antibodies that seek out and attach themselves to these
unwanted substances; these substances are generally referred to as
antigens.
Once your antibodies attach themselves to antigens, antigen-antibody
complexes are formed. Your immune system will work to eliminate these
antigen-antibody complexes from your body so that the foreign antigens
cannot harm your cells. But if enough of these complexes are formed,
your immune system may not be able to eliminate them as quickly as they
are formed. This can lead to some of these complexes getting deposited
into different tissues, where they can cause inflammation and damage.
Typically, the sites at which these complexes get deposited are
determined by your genetic predisposition.